%0 Journal Article
%T Unusual 5/5 fused bicyclosesquiterpenoids from Eupatorium adenophorum.
%A Geng H
%A Luo JH
%A Gu WJ
%A Zhang JJ
%A Yang YX
%A Yu Y
%J Fitoterapia
%V 170
%N 0
%D 2023 Oct 5
%M 37544332
%F 3.204
%R 10.1016/j.fitote.2023.105643
%X The chemical analysis on the aerial sections of Eupatorium adenophorum Spreng. resulted in the identification of four unprecedented 5/5 fused bicyclosesquiterpenoids, eupatorid A (1), and its analogues named eupatorester A-C (2-4) using various chromatographic techniques. Their structures were unambiguously confirmed by detailed spectroscopic investigations (including 1D, 2D-NMR and HRMS), and single crystal X-ray diffraction. The anti-inflammatory activities, in vitro tumor growth inhibitory activities and antibacterial activities of these compounds were evaluated.