%0 Journal Article
%T Infantile Myofibromatosis With Cutaneous, Visceral, and CNS Involvement: A Multimodal Approach to Therapy.
%A Gehle S
%A Quinsey C
%A McShane D
%A Thompson P
%A Quezada G
%J J Pediatr Hematol Oncol
%V 45
%N 7
%D 2023 10 1
%M 37526359
%F 1.17
%R 10.1097/MPH.0000000000002717
%X Infantile myofibromatosis (IM) is a rare benign tumor of infancy. Cases with solitary and multicentric disease usually spontaneously regress, but multicentric disease with visceral involvement carries a poor prognosis. Few cases of multicentric disease with central nervous system (CNS) involvement have been reported, and none report survival.<BR>We present a newborn with multicentric IM with cutaneous, visceral, and CNS involvement. She was treated with vinblastine, methotrexate, and the novel addition of intrathecal methotrexate with treatment response after 1 year of therapy.<BR>Multicentric IM with CNS involvement can be successfully treated with a multimodal approach of chemotherapy with the addition of intrathecal methotrexate and surgery.