%0 Multicenter Study
%T Clinical features and prognostic outcomes of angioimmunoblastic T cell lymphoma in an Asian multicenter study.
%A Chang EWY
%A Yang VS
%A Ong SY
%A Kang HX
%A Lim BY
%A de Mel S
%A Ng EKY
%A Poon ML
%A Tan YH
%A Chiang J
%A Poon E
%A Somasundaram N
%A Farid M
%A Tang T
%A Tao M
%A Khoo LP
%A Cheng CL
%A Huang D
%A Ong CK
%A Lim ST
%A Chan JY
%J Leuk Lymphoma
%V 64
%N 11
%D 2023 Nov-Dec 21
%M 37477443
暂无%R 10.1080/10428194.2023.2235043
%X In our Asian multicenter retrospective study, we investigated the clinical prognostic factors affecting the outcomes of AITL patients and identified a novel prognostic index relevant in the Asian context. In our 174-patient cohort, the median PFS and OS was 1.8 years and 5.6 years respectively. Age > 60, bone marrow involvement, total white cell count >12 × 109/L and raised serum lactate dehydrogenase were associated with poorer PFS and OS in multivariate analyses. This allowed for a prognostic index (AITL-PI) differentiating patients into low (0-1 factors, n = 64), moderate (2 factors, n = 59) and high-risk (3-4 factors, n = 49) subgroups with 5-year OS of 84.0%, 44.0% and 28.0% respectively (p < 0.0001). POD24 proved to be strongly prognostic (5-year OS 24% vs 89%, p < 0.0001). Exploratory gene expression studies were performed and disparate immune cell profiles and cell signaling signatures were seen in the low risk group as compared to the intermediate and high risk groups.