%0 Journal Article
%T Clinical Course and Recurrence in Transient Global Amnesia: A Study From the TEMPiS Telestroke Network.
%A Taheri S
%A Peters N
%A Zietz A
%A Abel B
%A Hubert G
%A Barinka F
%A Wiestler H
%A Kovacic I
%A Linker R
%A Schlachetzki F
%A Backhaus R
%J J Clin Neurol
%V 19
%N 6
%D 2023 Nov 1
%M 37455507
%F 2.566
%R 10.3988/jcn.2022.0368
%X <B>OBJECTIVE: </B>While the clinical hallmarks of transient global amnesia (TGA) are well defined, its pathophysiological causes are poorly understood. Specifically, risk factors for recurrences are yet to be determined.<BR><B>METHODS: </B>This retrospective study analyzed TGA cases diagnosed and treated within the TEMPiS telestroke network and a university stroke center in Germany. Demographic and clinical data were assessed and characteristics of TGA episodes were recorded, such as season of occurrence, trigger factors, duration, and concomitant symptoms. Follow-up of the potential recurrence of TGA was performed using a standardized questionnaire.<BR><B>RESULTS: </B>Overall 109 patients were included (age 64±8 years [mean±SD], 59.6% female). The most common vascular risk factor was arterial hypertension (60.6%), and other concomitant conditions included migraine (11.9%), hypothyroidism (22.9%), and atrial fibrillation (4.6%). The most frequent concomitant clinical feature accompanying the TGA episode at admission was elevated blood pressure (48.6%). Nineteen patients experienced at least one recurrent TGA episode. Migraine and hypothyroidism were only observed in subjects with a single TGA episode without recurrence (migraine: 14.4% without recurrence vs. none in the recurrence group, p=0.02; hypothyroidism: 27.8% without recurrence vs. none in the recurrence group, p=0.009). In contrast, atrial fibrillation was more common in subjects with TGA recurrence (p<0.001).<BR><B>CONCLUSIONS: </B>Arterial hypertension is prevalent in TGA patients, with elevated blood pressure being the most-frequent concomitant condition. In our cohort, recurrence of TGA occurred in approximately one-fifth of patients. Concomitant conditions such as migraine, hypothyroidism, and atrial fibrillation occurred at different frequencies in the two groups.