%0 Case Reports
%T The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines.
%A Quaedvlieg HJL
%A Polderman FN
%A Borkent M
%A Jonge HJM
%A Annema PA
%A Derijks LJJ
%A Sikma MA
%A Bethlehem C
%J Curr Drug Saf
%V 19
%N 2
%D 2024 Jul 14
%M 37455454
暂无%R 10.2174/1574886318666230714105801
%X Mercaptopurine, a thiopurine, is used in various disorders of immune regulation, such as autoimmune hepatitis. Thiopurine metabolism is complex with risk for overdosing, especially when metabolism is impaired by liver dysfunction. Hepatotoxicity may be due to mercaptopurine overdose and is often reversible after prompt cessation of the drug.<BR>Treatment of thiopurine toxicity is mainly supportive and literature on enhanced elimination by renal replacement therapy is ambiguous.<BR>In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.