%0 Journal Article
%T A risk scoring system for early diagnosis of anastomotic leakage after subtotal esophagectomy for esophageal cancer.
%A Sugita S
%A Miyata K
%A Shimizu D
%A Ebata T
%A Yokoyama Y
%J Jpn J Clin Oncol
%V 53
%N 10
%D 2023 Oct 4
%M 37370213
%F 2.925
%R 10.1093/jjco/hyad072
%X <B>BACKGROUND: </B>Anastomotic leakage (AL) is one of the most critical postoperative complications after subtotal esophagectomy in patients with esophageal cancer. This study attempted to develop an optimal scoring system for stratifying the risk for AL.<BR><B>METHODS: </B>The study included 171 patients who underwent subtotal esophagectomy for esophageal cancer followed by esophagogastrostomy in the cervical region from January 2011 to April 2021 at Nagoya University Hospital. AL was defined by radiologic or endoscopic evidence of anastomotic breakdown using some modalities. A risk scoring system for an early diagnosis of AL was established using factors determined in the multivariate analysis. A score was calculated for each patient, and the patients were classified into three categories according to the risk for AL: low-, intermediate- and high-risk. The trend of the risk for AL among the categories was evaluated.<BR><B>RESULTS: </B>Twenty-nine patients (17%) developed AL. Multivariate analysis demonstrated that sinistrous gross features of drain fluid (P < 0.001; odds ratio (OR), 10.2), radiologic air bubble sign (P < 0.001; OR, 15.0) and the level of drain amylase ≥280 U/L on postoperative Day 7 (P < 0.001; OR, 9.0) were significantly associated with AL. According to the matching number of the above three risk factors and categorization into three risk groups, the incidence of AL was 6.1% (8/131) in the low-risk group, 45.5% (15/33) in the intermediate-risk group and 85.7% (6/7) in the high-risk group (area under curve, 0.81; 95% confidence interval, 0.72-0.90).<BR><B>CONCLUSIONS: </B>The present AL-risk scoring system may be useful in postoperative patient care after subtotal esophagectomy.