%0 Journal Article
%T Clinical characteristics and outcome correlates of Chinese patients with takotsubo syndrome: Results from the first Chinese takotsubo syndrome registry.
%A Chong TK
%A Chen J
%A Lyu L
%A Wei Y
%A Liu Y
%A Wu L
%A Tao Y
%A Jiang L
%A Sun Z
%A Li D
%A Guan Q
%A Cheng F
%A Ding Y
%A Miao P
%A Lu C
%A Lei J
%A Wei T
%A Zhu T
%A Liu K
%J Int J Cardiol
%V 387
%N 0
%D 2023 09 15
%M 37355242
%F 4.039
%R 10.1016/j.ijcard.2023.131129
%X To investigate clinical features and outcomes of Chinese patients with Takotsubo syndrome (TTS).<BR>We established the first Chinese Registry of Takotsubo Syndrome (ChiTTS Registry) and analyzed demographic, clinical, therapeutical, and outcome data to characterize clinical and outcome features of Chinese TTS patients.<BR>In 112 enrolled patients in the ChiTTS registry from 02/01/2016 to 12/28/2021, the mean age was 59.4 ± 18.7 years old, and 27.7% were men. A total of 41.1% patients experienced respiratory and circulatory complications during hospitalization, and 17.3% patients developed cardiogenic shock. Physical triggers, dyspnea, tachycardia, and younger age (< 70 years old) predicted in-hospital complications. The MACCE rate during follow up was 13.9% per patient per year and the rate of all-cause death was 12.8% per patient per year. TTS patients with in-hospital complications developed more long-term MACCE (24.6% vs. 6.6% per patient-year, P < 0.001) and higher all-cause mortality (21.9% vs. 6.6% per patient-year, P = 0.001) than those without. The Kaplan-Meier survival analysis showed that more MACCE occurred in TTS patients with tachycardia during 3-year follow-up (HR 4.18; 95% CI 1.80-9.74; log-rank test P < 0.001). Among all medications at discharge, only beta-blocker was associated with reduced long-term MACCE (HR: 0.35; 95% CI: 0.12-0.996; P = 0.049).<BR>We investigated clinical and outcome features of patients in the first Chinese TTS Registry. Tachycardiac TTS patients developed more inpatient and long-term adverse cardiovascular events.