%0 Journal Article %T Multicentric Case Series and Literature Review of Coccidioidal Otomastoiditis. %A Schwartz IS %A Marek C %A Sandhu H %A Abdelmonem A %A Petersen G %A Dishner E %A Heidari A %A Thompson GR %J Emerg Infect Dis %V 29 %N 7 %D 2023 07 %M 37347877 %F 16.126 %R 10.3201/eid2907.230129 %X Coccidioidomycosis involving the ear, mastoid bone, or both is uncommon. We describe 5 new cases from the United States and review 4 cases reported in the literature of otomycosis and mastoiditis caused by Coccidioides. Of the 9 cases, 8 were linked to residence in or travel to California. Two patients had poorly controlled diabetes mellitus, 7 had otomastoiditis, 1 had otitis externa without mastoid involvement, and 1 had mastoiditis without otic involvement. Four patients had concurrent or prior pulmonary coccidioidomycosis. Ipsilateral facial nerve palsies developed in 2 patients. All patients received antifungal treatment for varying durations, and 8 of the 9 patients underwent surgical debridement. Clinicians should consider coccidioidomycosis as a differential diagnosis for otomastoiditis in patients with geographic risks.