%0 Journal Article
%T The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome.
%A Davey NE
%A Simonetti L
%A Ivarsson Y
%J Curr Opin Struct Biol
%V 80
%N 0
%D 2023 06 24
%M 37099901
%F 7.786
%R 10.1016/j.sbi.2023.102593
%X Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.