%0 Case Reports %T Zero-contrast IVUS-guided complex PCI in a patient with NSTE-ACS and severe renal impairment. %A Moretti F %A Rondi M %A Ottani F %J Catheter Cardiovasc Interv %V 101 %N 6 %D 2023 05 %M 36994869 %F 2.585 %R 10.1002/ccd.30651 %X A 76-year-old male with severe comorbidities and multiple cardiovascular risk factors including stage IV chronic kidney disease presents with non-ST-elevation myocardial infarction. An ultra-low contrast invasive coronary angiography using the DyeVert system and iso-osmolar contrast agent revealed a multivessel disease with heavy calcifications involving the left main stem and its bifurcation requiring a complex percutaneous coronary intervention. Because of the high risk of contrast-induced acute kidney injury, a zero-contrast intervention was performed using intravascular ultrasound guidance and dedicated stenting techniques with optimal imaging, clinical, and renal outcomes. Zero-contrast policies can be safely implemented even in complex clinical scenarios but at least two orthogonal angiographic projections should always be acquired to rule out distal complications.