%0 Journal Article
%T Clinical Significance of Corneal Striae in Thyroid Associated Orbitopathy.
%A Liao X
%A Aljufairi FMAA
%A Lai KKH
%A Chan KKW
%A Jia R
%A Chen W
%A Hu Z
%A Wei Y
%A Chu WCW
%A Tham CCY
%A Pang CP
%A Chong KKL
%J J Clin Med
%V 12
%N 6
%D Mar 2023 15
%M 36983285
%F 4.964
%R 10.3390/jcm12062284
%X <B>OBJECTIVE: </B>To elucidate the clinical implications of corneal striae (CS) in thyroid associated orbitopathy (TAO) patients.<BR><B>METHODS: </B>In this cross-sectional study, the presence of CS was confirmed after topical fluorescein staining on a slit lamp for consecutive treatment-naive TAO patients. Orbital parameters, including margin reflex distances, lagophthalmos, exophthalmos, intraocular pressure and radiological measurements, were compared between eyes with and without CS. The largest cross-sectional areas of each rectus muscle were measured by segmenting the T1-weighted (T1W) magnetic resonance images (MRI). The logistic regression analyses were used to evaluate the associations between CS and orbital parameters and rectus muscle measurements.<BR><B>RESULTS: </B>Fifty-three consecutive TAO patients (presenting age 46.47 ± 14.73 years, clinical activity score 1.77 ± 1.25) who had unilateral CS were enrolled. In univariate analysis, both the degree of lagophthalmos and the area of the levator palpebrae superioris-superior rectus complex (LPS/SR) on T1W MRI were significantly larger in CS eyes compared to eyes without CS (p < 0.05). Multivariate analyses showed that CS in TAO patients were significantly associated with the degree of lagophthalmos (OR = 1.75, 95% CI: 1.18-2.61, p < 0.05) and LPS/SR area (OR = 19.27, 95% CI: 1.43-259.32, p < 0.05) but not with the other parameters. CS could predict LPS/SR enlargement and larger lagophthalmos in TAO (p < 0.05). The largest cross-sectional areas of LPS/SR and inferior rectus were positively correlated with clinical activity scores (p < 0.05).<BR><B>CONCLUSIONS: </B>The presence of CS in TAO eye is significantly associated with LPS/SR enlargement and worse lagophthalmos. CS might be evaluated further as a potential ocular surface biomarker to identify upper lid and LPS/SR involvement in TAO.