%0 Case Reports
%T Case report: Successful anterior temporal lobectomy in drug-resistant temporal lobe epilepsy associated with Sotos syndrome.
%A Favi Bocca L
%A Pereira Rodrigues T
%A Bortholin T
%A Targas Yacubian EM
%A Carrete Júnior H
%A Guaranha M
%A Silva Centeno R
%J Front Neurol
%V 14
%N 0
%D 2023
%M 36970544
%F 4.086
%R 10.3389/fneur.2023.1126327
%X The Sotos syndrome is an autosomal dominant disorder characterized by haploinsufficiency of NSD1 gene, with some individuals affected by epilepsy and, rarely, drug-resistant seizures. A 47-years-old female patient with Sotos syndrome was diagnosed with focal-onset seizures in left temporal lobe, left-side hippocampal atrophy, and neuropsychological testing with decreased performance in several cognitive domains. Patient was treated with left-side temporal lobe resection and developed complete awake seizure control in 3-years of follow-up, with marked improvement in quality-of-life. In selected, clinically concordant patients, resective surgeries may play a significant role in improving patient's quality of life and seizure control.