%0 Journal Article
%T Synthesis of Cationic Biphen[4, 5]arenes as Biofilm Disruptors.
%A Du X
%A Ma M
%A Zhang Y
%A Yu X
%A Chen L
%A Zhang H
%A Meng Z
%A Jia X
%A Chen J
%A Meng Q
%A Li C
%J Angew Chem Int Ed Engl
%V 62
%N 21
%D 05 2023 15
%M 36929684
%F 16.823
%R 10.1002/anie.202301857
%X Since bacteria in biofilms are inherently resistant to antibiotics and biofilm-associated infections pose a serious threat to global public health, new therapeutic agents and schemes are urgently needed to meet clinical requirements. Here two quaternary ammonium-functionalized biphen[n]arenes (WBPn, n=4, 5) were designed and synthesized with excellent anti-biofilm potency. Not only could they inhibit the assembly of biofilms, but also eradicate intractable mature biofilms formed by Gram-positive S. aureus and Gram-negative E. coli bacterial strains. Moreover, they could strongly complex a conventional antibiotic, cefazolin sodium (CFZ) with complex stability constants of (7.41±0.29)×104  M-1 for CFZ/WBP4 and (4.98±0.49)×103  M-1 for CFZ/WBP5. Combination of CFZ by WBP4 and WBP5 synergistically enhanced biofilm eradication performance in vitro and statistically improved healing efficacy on E. coli-infected mice models, providing a novel supramolecular strategy for combating biofilm-associated infections.