%0 Systematic Review
%T The Association between COVID-19 and Reactive Arthritis: A Systematic Review of Case Reports and Case Series.
%A Namakin K
%A Sadeghzadeh S
%A Tamimi A
%A Abdolzadeh A
%A Khanjani Z
%A Ebrahimi N
%A Abdolmohammadi G
%A Golshan A
%A Fardoost S
%A Masrouri S
%A Hajikhani B
%A Salimi Chirani A
%A Zangiabadian M
%A Javad Nasiri M
%J Curr Rheumatol Rev
%V 19
%N 4
%D Mar 2023 16
%M 36927426
暂无%R 10.2174/1573397119666230316091809
%X <B>BACKGROUND: </B>Reactive arthritis (ReA) is a joint inflammation that follows an infection at a distant site, often in the gastrointestinal or urogenital tract. Since the emergence of COVID-19 in January 2020, several case reports have suggested a relation between reactive arthritis and severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), due to the novelty of the disease, most findings were reported in the form of case reports or case series, and a comprehensive overview is still lacking.<BR><B>METHODS: </B>We searched PubMed/Medline and Embase to identify studies addressing the association between ReA and COVID-19. The following terms were used: ("Reactive Arthritis" OR "Post-Infectious Arthritis" OR "Post Infectious Arthritis") AND ("COVID-19" OR "SARS-CoV-2" OR "2019-nCoV").<BR><B>RESULTS: </B>A total number of 35 reports published up to February 16th, 2022, were included in this study. A wide range of ages was affected (mean 41.0, min 4 max 78), with a higher prevalence of males (61.0%) from 16 countries. The number and location of the affected joints were different in included patients, with a higher prevalence of polyarthritis in 41.5% of all cases. Cutaneous manifestations and visual impairments were found as the most common associated symptoms. Most patients (95.1%) recovered, with a mean recovery time of 24 days. Moreover, arthritis induced by COVID-19 seems to relieve faster than ReA, followed by other infections.<BR><B>CONCLUSIONS: </B>ReA can be a possible sequel of COVID-19 infection. Since musculoskeletal pain is a frequent symptom of COVID-19, ReA with rapid onset can easily be misdiagnosed. Therefore, clinicians should consider ReA a vital differential diagnosis in patients with post-COVID-19 joint swelling. Additional studies are required for further analysis and to corroborate these findings.