%0 Journal Article
%T Ten-year survival of children with trisomy 13 or trisomy 18: a multi-registry European cohort study.
%A Glinianaia SV
%A Rankin J
%A Tan J
%A Loane M
%A Garne E
%A Cavero-Carbonell C
%A de Walle HEK
%A Gatt M
%A Gissler M
%A Klungsøyr K
%A Lelong N
%A Neville A
%A Pierini A
%A Tucker DF
%A Urhoj SK
%A Wellesley DG
%A Morris JK
%J Arch Dis Child
%V 108
%N 6
%D 06 2023 7
%M 36882305
%F 4.92
%R 10.1136/archdischild-2022-325068
%X To investigate the survival to 10 years of age of children with trisomy 13 (T13) and children with trisomy 18 (T18), born 1995-2014.<BR>Population-based cohort study that linked mortality data to data on children born with T13 or T18, including translocations and mosaicisms, from 13 member registries of EUROCAT, a European network for the surveillance of congenital anomalies.<BR>13 regions in nine Western European countries.<BR>252 live births with T13 and 602 with T18.<BR>Survival at 1 week, 4 weeks and 1, 5 and 10 years of age estimated by random-effects meta-analyses of registry-specific Kaplan-Meier survival estimates.<BR>Survival estimates of children with T13 were 34% (95% CI 26% to 46%), 17% (95% CI 11% to 29%) and 11% (95% CI 6% to 18%) at 4 weeks, 1 and 10 years, respectively. The corresponding survival estimates were 38% (95% CI 31% to 45%), 13% (95% CI 10% to 17%) and 8% (95% CI 5% to 13%) for children with T18. The 10-year survival conditional on surviving to 4 weeks was 32% (95% CI 23% to 41%) and 21% (95% CI 15% to 28%) for children with T13 and T18, respectively.<BR>This multi-registry European study found that despite extremely high neonatal mortality in children with T13 and T18, 32% and 21%, respectively, of those who survived to 4 weeks were likely to survive to age 10 years. These reliable survival estimates are useful to inform counselling of parents after prenatal diagnosis.