%0 Journal Article
%T Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review.
%A Raffone A
%A Raimondo D
%A Maletta M
%A Travaglino A
%A Renzulli F
%A Neola D
%A De Laurentiis U
%A De Laurentiis F
%A Mabrouk M
%A Ianieri MM
%A Seracchioli R
%A Casadio P
%A Mollo A
%J Cancers (Basel)
%V 15
%N 4
%D Feb 2023 10
%M 36831484
%F 6.575
%R 10.3390/cancers15041142
%X Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the clinicopathological features and survival outcomes of women with EC-AIA through a systematic review of the literature. Six electronic databases were searched, from 2002 to 2022, for all peer-reviewed studies that reported EC-AIA cases. Thirty-seven EC-AIA patients from 27 case reports and four case series were included in our study. In our analysis, EC-AIA appeared as a rare disease that mainly occurs in menopausal women, shares symptoms with endometrial cancer, and is challenging to diagnose preoperatively. Differently from EC, it shows a higher prevalence of the non-endometrioid histotype, advanced FIGO stages, and p53-signature, which might be responsible for its worse prognosis. Future studies are necessary, to confirm our findings and further investigate this rare condition.