%0 Journal Article
%T A Case of Minimally Progressive Prodromal Alzheimer's Disease.
%A Rosenbloom MH
%A Barclay T
%J J Alzheimers Dis Rep
%V 7
%N 1
%D 2023
%M 36777327
暂无%R 10.3233/ADR-220065
%X Prodromal Alzheimer's disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient's neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression.