%0 Case Reports
%T Advanced Appendiceal Cancer with Systematic Metastasis without Gastrointestinal Symptoms Found by Subcutaneous Tumor.
%A Nakamura S
%A Ochiai Y
%A Nishihara Y
%A Koyanagi A
%A Miura Y
%A Kikuchi D
%A Takazawa Y
%A Kuroyanagi H
%A Hoteya S
%J Intern Med
%V 62
%N 18
%D Sep 2023 15
%M 36754410
%F 1.282
%R 10.2169/internalmedicine.0597-22
%X An 86-year-old woman with a subcutaneous nodule in her left axilla visited our hospital. She had no gastrointestinal symptoms, but contrast-enhanced computed tomography revealed a cecal mass and systemic metastasis, including cutaneous, bone, peritoneal dissemination and ascites. Colonoscopy revealed a circumferential, elevated cecal lesion. She underwent right hemicolectomy to prevent colon obstruction. The pathological diagnosis was poorly differentiated adenocarcinoma (por1>tub2>muc) arising from the appendix with a BRAFV600E mutation and microsatellite instability-high. Chemotherapy was administered, and she is currently still alive and undergoing chemotherapy. We describe a rare case of advanced appendiceal cancer without gastrointestinal symptoms diagnosed due to cutaneous metastasis.