%0 Journal Article
%T Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
%A Sun YS
%A Wang ZW
%A Gao Z
%A Zhao W
%A Thakur K
%A Zhong Q
%A Wei ZJ
%J Curr Res Food Sci
%V 5
%N 0
%D 2022
%M 36686366
%F 6.269
%R 10.1016/j.crfs.2022.05.009
%X In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clinical colon cancer patients.