%0 Journal Article
%T Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation.
%A Spils J
%A Wirth T
%A Nachtsheim BJ
%J Beilstein J Org Chem
%V 19
%N 0
%D 2023
%M 36686040
%F 2.544
%R 10.3762/bjoc.19.2
%X We describe a multi-step continuous-flow procedure for the generation of six-membered diaryliodonium salts. The accompanying scalability and atom economy are significant improvements to existing batch methods. Benzyl acetates are submitted to this two-step procedure as highly available and cheap starting materials. An acid-catalyzed Friedel-Crafts alkylation followed by an anodic oxidative cyclization yielded a defined set of cyclic iodonium salts in a highly substrate-dependent yield.