%0 Journal Article
%T Rejuvenating the Activity of Usual Antibiotics on Resistant Gram-Negative Bacteria: Recent Issues and Perspectives.
%A Tabcheh J
%A Vergalli J
%A Davin-Régli A
%A Ghanem N
%A Pages JM
%A Al-Bayssari C
%A Brunel JM
%J Int J Mol Sci
%V 24
%N 2
%D Jan 2023 12
%M 36675027
%F 6.208
%R 10.3390/ijms24021515
%X Antibiotic resistance continues to evolve and spread beyond all boundaries, resulting in an increase in morbidity and mortality for non-curable infectious diseases. Due to the failure of conventional antimicrobial therapy and the lack of introduction of a novel class of antibiotics, novel strategies have recently emerged to combat these multidrug-resistant infectious microorganisms. In this review, we highlight the development of effective antibiotic combinations and of antibiotics with non-antibiotic activity-enhancing compounds to address the widespread emergence of antibiotic-resistant strains.