%0 Case Reports
%T Adult onset Xanthogranuloma presenting as a solitary laryngeal localization: case report and review of literature.
%A Velletrani G
%A Francavilla B
%A Rosati V
%A Padial B
%A Anemona L
%A Girolamo SD
%J Arch Clin Cases
%V 9
%N 4
%D 2022
%M 36628161
暂无%R 10.22551/2022.37.0904.10221
%X Juvenile Xanthogranuloma (XG) is a rare disorder that belongs to the heterogeneous group of histiocytic neoplasms, characterized by a clonal expansion of non-Langerhans cell histiocytes that share a dermal macrophage phenotype. Although the head and neck region is the most common reported site of involvement by the Juvenile Xanthogranuloma family, laryngeal localization is extremely rare. We report a unique case of Adult Onset Xanthogranuloma with subglottic localization, presenting as a solitary laryngeal mass without other systemic or cutaneous lesions. A review of the previously described cases of laryngeal Xanthogranuloma has been performed, highlighting 7 cases of Juvenile Xanthogranuloma and only 3 cases of Adult Onset Xanthogranuloma. Despite the extreme rarity of laryngeal localization of XG, this histiocytic neoplasm should be considered as a differential diagnosis for laryngeal masses causing airway obstruction, even in the absence of other concomitant manifestations.