%0 Case Reports
%T Bilateral Cleft Lip and Palate in Ring Chromosome 7 Syndrome: A Case Report and Review of Clinical Characteristics.
%A Bangun K
%A Kreshanti P
%A Tania V
%A Ariani Aswin Y
%A Menna C
%A Aurino L
%J Cleft Palate Craniofac J
%V 61
%N 3
%D Mar 2024 9
%M 36624583
%F 1.915
%R 10.1177/10556656221149243
%X This report presents a case of ring chromosome 7 syndrome with bilateral cleft lip and palate. A four-year-old boy presented with bilateral cleft lip and palate, microcephaly, clenched toes, cafe-au-lait spots, a history of epilepsy, and severe intellectual disability. Genetic karyotyping revealed 46 XY r(7) (p22q36). His cheiloplasty and delayed palatoplasty were successful. A review of 22 previous r(7) patients revealed that 22.7% had cleft lip and/or palate. This case demonstrates the importance of a multidisciplinary evaluation for cleft patients, particularly those with syndromic features and global developmental delay.