%0 Journal Article
%T Variability in Hemispheric Functional Segregation Phenotypes: A Review and General Mechanistic Model.
%A Gerrits R
%J Neuropsychol Rev
%V 34
%N 1
%D Mar 2024 28
%M 36576683
%F 6.94
%R 10.1007/s11065-022-09575-y
%X Many functions of the human brain are organized asymmetrically and are subject to strong population biases. Some tasks, like speaking and making complex hand movements, exhibit left hemispheric dominance, whereas others, such as spatial processing and recognizing faces, favor the right hemisphere. While pattern of preference implies the existence of a stereotypical way of distributing functions between the hemispheres, an ever-increasing body of evidence indicates that not everyone follows this pattern of hemispheric functional segregation. On the contrary, the review conducted in this article shows that departures from the standard hemispheric division of labor are routinely observed and assume many distinct forms, each having a different prevalence rate. One of the key challenges in human neuroscience is to model this variability. By integrating well-established and recently emerged ideas about the mechanisms that underlie functional lateralization, the current article proposes a general mechanistic model that explains the observed distribution of segregation phenotypes and generates new testable hypotheses.