%0 Journal Article
%T Landscape of the intratumroal microenvironment in bladder cancer: Implications for prognosis and immunotherapy.
%A Bian Z
%A Chen J
%A Liu C
%A Ge Q
%A Zhang M
%A Meng J
%A Liang C
%J Comput Struct Biotechnol J
%V 21
%N 0
%D 2023
%M 36514337
%F 6.155
%R 10.1016/j.csbj.2022.11.052
%X <B>UNASSIGNED: </B>This study aims to present the landscape of the intratumoral microenvironment and by which establish a classification system that can be used to predict the prognosis of bladder cancer patients and their response to anti-PD-L1 immunotherapy.<BR><B>UNASSIGNED: </B>The expression profiles of 1554 bladder cancer cases were downloaded from seven public datasets. Single-sample gene set enrichment analysis (ssGSEA), univariate Cox regression analysis, and meta-analysis were employed to establish the bladder cancer immune prognostic index (BCIPI). Extensive analyses were executed to investigate the association between BCIPI and overall survival, tumor-infiltrated immunocytes, immunotherapeutic response, mutation load, etc.<BR><B>UNASSIGNED: </B>The results obtained from seven independent cohorts and meta-analyses suggested that the BCIPI is an effective classification system for estimating bladder cancer patients' overall survival. Patients in the BCIPI-High subgroup revealed different immunophenotypic outcomes from those in the BCIPI-Low subgroup regarding tumor-infiltrated immunocytes and mutated genes. Subsequent analysis suggested that patients in the BCIPI-High subgroup were more sensitive to anti-PD-L1 immunotherapy than those in the BCIPI-Low subgroup.<BR><B>UNASSIGNED: </B>The newly established BCIPI is a valuable tool for predicting overall survival outcomes and immunotherapeutic responses in patients with bladder cancer.