%0 Journal Article
%T Laser-Induced µ-Rooms for Osteocytes on Implant Surface: An In Vivo Study.
%A Veiko V
%A Karlagina Y
%A Zernitckaia E
%A Egorova E
%A Radaev M
%A Yaremenko A
%A Chernenko G
%A Romanov V
%A Shchedrina N
%A Ivanova E
%A Chichkov B
%A Odintsova G
%J Nanomaterials (Basel)
%V 12
%N 23
%D Nov 2022 28
%M 36500852
%F 5.719
%R 10.3390/nano12234229
%X Laser processing of dental implant surfaces is becoming a more widespread replacement for classical techniques due to its undeniable advantages, including control of oxide formation and structure and surface relief at the microscale. Thus, using a laser, we created several biomimetic topographies of various shapes on the surface of titanium screw-shaped implants to research their success and survival rates. A distinctive feature of the topographies is the presence of "µ-rooms", which are special spaces created by the depressions and elevations and are analogous to the µ-sized room in which the osteocyte will potentially live. We conducted the comparable in vivo study using dental implants with continuous (G-topography with µ-canals), discrete (S-topography with μ-cavities), and irregular (I-topography) laser-induced topographies. A histological analysis performed with the statistical method (with p-value less than 0.05) was conducted, which showed that G-topography had the highest BIC parameter and contained the highest number of mature osteocytes, indicating the best secondary stability and osseointegration.