%0 Review
%T Toxic Epidermal Necrolysis: A Review of Past and Present Therapeutic Approaches
%A Singh N
%A Phillips M
%J Skin Therapy Lett
%V 27
%N 5
%D 09 2022
%M 36469487
暂无%X Toxic epidermal necrolysis (TEN) is an immune mediated, severe cutaneous adverse drug reaction characterized by epidermal detachment affecting greater than 30% body surface area. The mortality rate of TEN exceeds 20% and is usually caused by infection and respiratory compromise. Withdrawal of the causative drug, supportive care, and adjuvant therapy improve prognosis. Over the past decade, randomized controlled trials and meta-analyses have supported a role for cyclosporine, tumor necrosis factor alpha inhibitors, and combination therapy with intravenous immune globulin and corticosteroids. This review summarizes the medical management of TEN in adult patients.