%0 Systematic Review
%T Targeted Therapies for Hepatocellular Carcinoma Treatment: A New Era Ahead-A Systematic Review.
%A Damaskos C
%A Garmpis N
%A Dimitroulis D
%A Garmpi A
%A Psilopatis I
%A Sarantis P
%A Koustas E
%A Kanavidis P
%A Prevezanos D
%A Kouraklis G
%A Karamouzis MV
%A Marinos G
%A Kontzoglou K
%A Antoniou EA
%J Int J Mol Sci
%V 23
%N 22
%D Nov 2022 15
%M 36430594
%F 6.208
%R 10.3390/ijms232214117
%X Hepatocellular carcinoma (HCC) remains one of the most common malignancies and the third cause of cancer-related death worldwide, with surgery being the best prognostic tool. Among the well-known causative factors of HCC are chronic liver virus infections, chronic virus hepatitis B (HBV) and chronic hepatitis virus C (HCV), aflatoxins, tobacco consumption, and non-alcoholic liver disease (NAFLD). There is a need for the development of efficient molecular markers and alternative therapeutic targets of great significance. In this review, we describe the general characteristics of HCC and present a variety of targeted therapies that resulted in progress in HCC therapy.