%0 Journal Article
%T Structural and functional conservation of the activating Ca2+ binding site in inositol 1,4.5-trisphosphate and ryanodine receptors.
%A Chen YS
%A Van Petegem F
%J Cell Calcium
%V 108
%N 0
%D 12 2022
%M 36370621
%F 4.69
%R 10.1016/j.ceca.2022.102671
%X Inositol 1,4,5-trisphosphate receptors (IP3Rs) and Ryanodine Receptors (RyRs) dictate the release of Ca2+ from the Endoplasmic (ER) and Sarcoplasmic Reticulum (SR). Arige et al [1] investigated the functional importance of specific Ca2+-coordinating residues, unambiguously confirming the activating Ca2+ binding site in the IP3R.