%0 Journal Article
%T Immunotherapy: State-of-the-art review of therapies and theratypes.
%A Agache I
%A Zemelka-Wiącek M
%A Shamji MH
%A Jutel M
%J J Allergy Clin Immunol
%V 150
%N 6
%D 12 2022
%M 36328808
%F 14.29
%R 10.1016/j.jaci.2022.10.007
%X Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation network. In this review, a summary of the most significant advances in immunotherapy is presented, addressing not only novel approaches to stratifying patients but also major controlled clinical trials and real-world evidence that strengthen the role of immunotherapy in the treatment of allergies.