%0 Journal Article
%T Non-HLA Antibodies and Their Role in Highly Sensitized Patients.
%A Roa-Bautista A
%A López-Del-Moral C
%A González-López E
%A Gutiérrez-Larrañaga M
%A Renuncio-García M
%A Castro-Hernández C
%A Mikhalkovich-Mikhalkovich D
%A Comins-Boo A
%A Irure-Ventura J
%A Rodrigo E
%A Ruiz San Millán JC
%A López-Hoyos M
%A San Segundo D
%J Transplant Proc
%V 54
%N 9
%D Nov 2022
%M 36319497
%F 1.014
%R 10.1016/j.transproceed.2022.10.011
%X <B>BACKGROUND: </B>The role of non-HLA antibody is gaining special attention in solid-organ transplantation and in highly sensitized (HS) patients because of its potential involvement in graft loss (GL) and/or antibody-mediated rejection (ABMR). The identification of non-HLA antibodies while listed may provide deeper information about the increased immunologic risk prior to transplant. We aimed to identify non-HLA antibodies pretransplant that could involve GL in HS patients.<BR><B>METHODS: </B>Nineteen pretransplant samples from HS patients who underwent transplant at the Marqués de Valdecilla University Hospital were studied for both HLA antibodies and a panel of 39 non-HLA antigens analyzed based on Luminex platform.<BR><B>RESULTS: </B>Eleven patient (57.9%) maintained the graft (KT group), whereas 8 (42.1%) had a GL within a median of 30 days. The median fluorescent intensity (MFI) of the 39 non-HLA antigens were compared within the groups, obtaining a statistically significant differences in protein tyrosine phosphatase receptor type N (P < .04) with a MFI mean of 1408 vs 4931 for KT and GL groups, respectively. However, no significant differences were observed in non-HLA MFI between ABMR and non-ABMR KT recipients.<BR><B>CONCLUSIONS: </B>The presence of non-HLA antibodies in HS is high. The levels of anti-protein tyrosine phosphatase receptor type N before transplant could indicate a potential risk of GL, although longitudinal studies with large number of cases are needed to define anti-non-HLA profiles of risk of ABMR.