%0 Journal Article
%T Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice.
%A Nugroho AB
%A Stafford N
%A Zi M
%A Prehar S
%A Potter R
%A Kwon D
%A Kohar YS
%A Triastuti E
%A Bui TA
%A Cartwright EJ
%A Oceandy D
%J JACC Basic Transl Sci
%V 7
%N 9
%D Sep 2022
%M 36317138
%F 9.531
%R 10.1016/j.jacbts.2022.05.008
%X Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.