%0 Journal Article
%T Anion-Driven Programmable Chiral Self-Sorting in Metal-Organic Cages and Structural Transformations between Heterochiral and Homochiral Cages.
%A Ghorai S
%A Natarajan R
%J Chemistry
%V 29
%N 6
%D Jan 2023 27
%M 36300703
%F 5.02
%R 10.1002/chem.202203085
%X When a racemic mixture of chiral building blocks self-assembles to form discrete molecular or supramolecular cages, the system can adopt either social or narcissistic chiral self-sorting. However, control over such chiral self-sorting is hard to achieve with a desired choice of outcome. Herein, we report anion templated high-fidelity chiral self-sorting during the coordination-driven self-assembly of [Pd2 L4 ] metal-organic cages, with a racemic mixture of an axially chiral ligand. Upon varying the counter-anions, the outcome of the choice of chiral self-sorting, whether social or narcissistic, leading to kinetically favored heterochiral or thermodynamically favored homochiral cages, can be controlled through specific anion encapsulation. Non-encapsulating anion afforded a mixture of all possible diastereomers. Anion exchange enabled structural transformations between the diastereomers and the conversion of the mixture of diastereomers into homochiral diastereomers.