%0 Journal Article
%T Hypermobile Ehlers-Danlos Syndrome: A Prodromal Subtype of Functional Movement Disorders?
%A Margolesky J
%A Puentes D
%A Espay AJ
%J Mov Disord Clin Pract
%V 9
%N 7
%D Oct 2022
%M 36247916
%F 4.514
%R 10.1002/mdc3.13545
%X <B>UNASSIGNED: </B>The phenotypic diversity of functional movement disorders (FMD) is considered a reflection of its many etiological subtypes. Ehlers-Danlos syndrome (EDS), a joint hypermobility syndrome, also has variable phenotypes, which may include functional symptoms.<BR><B>UNASSIGNED: </B>To determine the prevalence of combined diagnoses of FMD and EDS.<BR><B>UNASSIGNED: </B>We searched our Electronic Medical Records for patients carrying diagnostic codes for EDS and FMD. Further data extraction was done through chart review.<BR><B>UNASSIGNED: </B>Of 11,621 patients evaluated from January 1, 2016 to May 1, 2022, 16 carried a diagnosis of EDS, of which 9 (56.3%) were also diagnosed with FMD. Conversely, a diagnosis of FMD was documented in 190 (1.6%), of whom 16 (8.4%) were diagnosed with EDS. In all EDS-FMD cases, the diagnosis of EDS preceded the onset and diagnosis of FMD.<BR><B>UNASSIGNED: </B>The co-occurrence of FMD and EDS is beyond chance, suggesting association. EDS may represent a prodromal subtype of, and share common pathophysiologic features with, FMD.