%0 Journal Article
%T Microbial production of vitamin B5: current status and prospects.
%A Zhao K
%A Tang H
%A Zhang B
%A Zou S
%A Liu Z
%A Zheng Y
%J Crit Rev Biotechnol
%V 43
%N 8
%D Dec 2023 9
%M 36210178
%F 9.062
%R 10.1080/07388551.2022.2104690
%X Vitamin B5, also called D-pantothenic acid (D-PA), is a necessary micronutrient that plays an essential role in maintaining the physiological function of an organism. It is widely used in: food, medicine, feed, cosmetics, and other fields. Currently, the production of D-PA in industry heavily relies on chemical processes and enzymatic catalysis. With an increasing demand on the market, replacing chemical-based production of D-PA with microbial fermentation utilizing renewable resources is necessary. In this review, the physiological role and applications of D-PA were firstly introduced, after which the biosynthesis pathways and enzymes will be summarized. Subsequently, a series of cell factory development strategies for excessive D-PA production are analyzed and discussed. Finally, the prospect of microbial production of D-PA production has been prospected.