%0 Journal Article
%T Investigation of the effects of marsupialization on histomorphological and immunohistochemical markers of odontogenic keratocysts.
%A Baris E
%A Secen A
%A Karabulut S
%A Gultekin SE
%A Baris E
%A Secen A
%A Karabulut S
%A Gultekin SE
%A Baris E
%A Secen A
%A Karabulut S
%A Gultekin SE
%J Niger J Clin Pract
%V 25
%N 9
%D Sep 2022
%M 36149218
暂无%R 10.4103/njcp.njcp_103_22
%X <B>UNASSIGNED: </B>Despite its extensive bone resorption and high recurrence rate, marsupialization is the preferred option in the treatment of odontogenic keratocysts (OKCs).<BR><B>UNASSIGNED: </B>We aimed to assess the effect of marsupialization on histomorphological and biochemical markers of OKCs.<BR><B>UNASSIGNED: </B>The study is conducted on 48 paraffin blocks of 24 OKC cases between the years 2012 to 2018. The main clinical, radiographic, and histomorphometric measurements were recorded. Immunohistochemical staining with E-cadherin, Ki67, IL1α, TNFα, Slug, and Snail were performed and compared for pre-marsupialization and post-marsupialization values.<BR><B>UNASSIGNED: </B>OKCs mostly located in the mandibular posterior region. The mean marsupialization period was 8.8 ± 6.5 (3-25) months. The mean radiographic size of OKC (57.1 ± 53.5 mm) was significantly reduced after marsupialization (22.6 ± 19.9 mm, P = 0.002). Histologically, significantly increased thickness of the OKC epithelium (p = 0.002) and collagen production (p = 0.034) was detected after marsupialization. The post-marsupialization group showed positive correlation of inflammation score to both TNFα (r: 0.69, P < 0.001) and IL-1α (r: 0.58, P = 0.008) expressions in connective tissue. Among immunohistochemical parameters, only Slug expression was significantly higher after marsupialization (p = 0.019).<BR><B>UNASSIGNED: </B>Our study suggests that increased Slug expression may enable the second surgery by increasing fibrosis in the cyst wall.