%0 Journal Article
%T Idiopathic hyperammonemic encephalopathy secondary to gemcitabine-cisplatin treatment.
%A Verkerk K
%A Otten HM
%A Huitema ADR
%J Cancer Chemother Pharmacol
%V 0
%N 0
%D Sep 2022 20
%M 36127544
%F 3.288
%R 10.1007/s00280-022-04476-6
%X Idiopathic hyperammonemic encephalopathy is a rare complication of chemotherapy, which has previously mainly been associated with L-asparaginase, cytarabine and 5-FU. We present a case following treatment with gemcitabine-cisplatin in a patient with cholangiocarcinoma. The etiology of chemotherapy-induced idiopathic hyperammonemic encephalopathy remains unclear and existing theories differ per chemotherapeutic agent. Physicians treating patients with gemcitabine-cisplatin should be aware of the possibility of this complication, especially because it is treatable when recognized early.