%0 Journal Article
%T It's the water! The open and shut case of drug-induced integrin activation.
%A Coller BS
%J Cell
%V 185
%N 19
%D 09 2022 15
%M 36113425
%F 66.85
%R 10.1016/j.cell.2022.08.015
%X Integrin receptors are established drug targets, but many of the drugs that have been developed act as partial agonists, inducing the receptor into a high-affinity, ligand-binding state. Lin et al. discovered a general mechanism to circumvent this problem-stabilizing a key water molecule that prevents receptor activation. Their findings are likely to impact future therapeutic development.