%0 Journal Article
%T Infection of young foals with Equine Parvovirus-Hepatitis following a fatal non-biologic case of Theiler's disease.
%A Meister TL
%A Arroyo LG
%A Shanahan R
%A Papapetrou MA
%A Reinecke B
%A Brüggemann Y
%A Todt D
%A Stang A
%A Hazlett M
%A Baird JD
%A Steinmann E
%J Vet Microbiol
%V 274
%N 0
%D Sep 2022 5
%M 36088712
%F 3.246
%R 10.1016/j.vetmic.2022.109557
%X Theiler's disease (TD) is a (sub-)acute hepatitis in adult horses and one of the most common causes of acute hepatic failure. Recent findings indicate that equine parvovirus hepatitis (EqPV-H) likely causes TD and that its transmission occurs via iatrogenic and/or natural routes. Following the death of an EqPV-H positive mare with TD, close-contact mares and foals in the same paddock were monitored to evaluate if there was any evidence of EqPV-H. For this purpose, the serum of close contact horses was examined 6 and 42 days after the mare's death for the presence of EqPV-H DNA and changes in liver-associated serum biochemical parameters. The foals had higher EqPV-H viral loads than the mares. Apart from the mare that was euthanized, none of the horses included in this study showed signs of severe disease and nor did they have particularly elevated liver enzymes. Nucleotide sequence analysis revealed no major differences between the viral DNA detected in the serum of the dead mare and any of the in-contact horses. In conclusion, our data confirmed previous findings that horizontal transmission of EqPV-H may occur through close contact between horses.