%0 Journal Article
%T Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress.
%A Chen Y
%A Shen J
%A Nilsson AH
%A Goncalves I
%A Edsfeldt A
%A Engström G
%A Zaigham S
%A Melander O
%A Orho-Melander M
%A Rauch U
%A Venuraju SM
%A Lahiri A
%A Liang C
%A Nilsson J
%A Chen Y
%A Shen J
%A Nilsson AH
%A Goncalves I
%A Edsfeldt A
%A Engström G
%A Zaigham S
%A Melander O
%A Orho-Melander M
%A Rauch U
%A Venuraju SM
%A Lahiri A
%A Liang C
%A Nilsson J
%J JACC Basic Transl Sci
%V 7
%N 8
%D Aug 2022
%M 36061342
%F 9.531
%R 10.1016/j.jacbts.2022.03.013
%X Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.