%0 Journal Article
%T Role of muscle biopsy in diagnosis of extraocular muscles enlargement.
%A Abouelatta MM
%A Shalaby OE
%A Awara AM
%A Kikkawa DO
%A Liu CY
%A Eldesouky MA
%J Int Ophthalmol
%V 43
%N 3
%D Mar 2023
%M 36040550
%F 2.029
%R 10.1007/s10792-022-02470-8
%X <B>OBJECTIVE: </B>To study the role of muscle biopsy in patients with enlarged extraocular muscles.<BR><B>METHODS: </B>A retrospective review of 31 patients who underwent biopsy for extraocular muscle enlargement. Characteristics, including signs, symptoms, imaging findings, and histopathological assessment were examined.<BR><B>RESULTS: </B>Chronic inflammatory disorders represented the most common cause of the muscle enlargement followed by malignancy/metastasis. Multiple muscle involvement was more consistent with benign diseases, whereas single muscle involvement was more consistent with malignant causes. Positive predictive value of muscle biopsy was 0.52 for determining a specific cause of the muscle enlargement.<BR><B>CONCLUSIONS: </B>Muscle biopsy is the standard for diagnosis in patients with extraocular muscle enlargement. This diagnostic test should be performed in every case of non-resolving muscle enlargement, with a specific diagnosis being made in over half of cases.