%0 Journal Article
%T Diagnostic utility of specific abnormal EEG patterns in children for determining epilepsy phenotype and presence of structural brain abnormalities.
%A Ashour M
%A Minato E
%A Alawadhi A
%A Berrahmoune S
%A Simard-Tremblay E
%A Poulin C
%A Myers KA
%A Ashour M
%A Minato E
%A Alawadhi A
%A Berrahmoune S
%A Simard-Tremblay E
%A Poulin C
%A Myers KA
%J Heliyon
%V 8
%N 8
%D Aug 2022
%M 36033323
%F 3.776
%R 10.1016/j.heliyon.2022.e10172
%X <B>UNASSIGNED: </B>Estimate sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of EEG findings: centrotemporal spikes, photoparoxysmal response, asymmetric photic driving, and asymmetric sleep spindles, for epilepsy phenotype and presence of structural brain abnormalities.<BR><B>UNASSIGNED: </B>In this case-control study we reviewed children referred for EEG over a 4-year period, with at least one of centrotemporal spikes, photoparoxysmal response, asymmetric photic driving, or asymmetric sleep spindles. This cohort was analyzed in combination with a research database of pediatric patients with seizures.<BR><B>UNASSIGNED: </B>Centrotemporal spikes had 100% sensitivity for childhood epilepsy with centrotemporal spikes or atypical childhood epilepsy with centrotemporal spikes, but lower specificity (70%) and PPV (58%). Photoparoxysmal response had high specificity (92%) and NPV (92%) for genetic generalized epilepsy. Asymmetric photic driving had low sensitivity for structural brain abnormalities (17%), with specificity 80%. In contrast, asymmetric sleep spindles had much higher sensitivity and specificity, 44% and 97%, respectively.<BR><B>UNASSIGNED: </B>Although centrotemporal spikes are classically associated with childhood epilepsy with centrotemporal spikes, these discharges are seen in other conditions. Photoparoxysmal response is highly indicative of a genetic generalized epilepsy, though may be seen in other epilepsy phenotypes. Relative attenuation of sleep spindles is a more reliable indicator of structural brain malformation than asymmetric photic driving.<BR><B>UNASSIGNED: </B>The quantitative diagnostic utility of EEG findings should be considered when incorporating these results into clinical decision-making.