%0 Journal Article
%T Combined Hepatocellular-Cholangiocarcinoma: An Update on Pathology and Diagnostic Approach.
%A Choi JH
%A Ro JY
%A Choi JH
%A Ro JY
%A Choi JH
%A Ro JY
%J Biomedicines
%V 10
%N 8
%D Jul 2022 29
%M 36009374
%F 4.757
%R 10.3390/biomedicines10081826
%X Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma displaying both hepatocytic and cholangiocytic differentiation within the same tumor. Relative to classic hepatocellular carcinoma (HCC), cHCC-CCA has more aggressive behavior and a poorer prognosis. Though recent advances have improved our understanding of the biology underlying cHCC-CCAs, they remain diagnostically challenging for pathologists because of their morphologic and phenotypic diversity. Accurate diagnosis of cHCC-CCA is important for patient management and prognostication. Herein, we review recent updates on cHCC-CCA, focusing on tumor classification, pathology, and diagnostic approach.