%0 Case Reports
%T Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma.
%A Bonometti A
%A Aronico N
%A Santacroce G
%A Fraticelli S
%A Lucioni M
%A Cartia CS
%A Vanoli A
%A Latorre MA
%A Arcaini L
%A Paulli M
%A Di Sabatino A
%A Bonometti A
%A Aronico N
%A Santacroce G
%A Fraticelli S
%A Lucioni M
%A Cartia CS
%A Vanoli A
%A Latorre MA
%A Arcaini L
%A Paulli M
%A Di Sabatino A
%J Front Oncol
%V 12
%N 0
%D 2022
%M 35992811
%F 5.738
%R 10.3389/fonc.2022.934566
%X Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumferential thickening of terminal ileum, for which the patient underwent an urgent 20-cm-long ileal resection. Histopathological and immunophenotypic analysis revealed a plasma cell neoplasm of the ileum. Subsequent investigations found a serum monoclonal immunoglobulin A component, an osteolytic lesion of the left jaw, and a clonal bone marrow plasma cell infiltrate carrying 1q21 amplification. Given the final diagnosis of plasma cell myeloma (PCM), the patient underwent a VMD (bortezomib, melphalan, and dexamethasone) chemotherapy regimen, achieving a complete remission after a 12-month treatment. For disease relapse, two further chemotherapy regimens were later attempted. At the last follow-up 4 years after the diagnosis, the patient is still alive. This case draws attention to the extramedullary presentation of plasma cell neoplasms, even if rare, as a prompt diagnosis seems to result in a better prognosis. In addition, it highlights the relevance of a multidisciplinary approach, involving gastroenterologists, hematologists, and pathologists, to the diagnosis and management of these neoplasms.