%0 Case Reports
%T GM-CSF antibodies in artificial stone associated silicoproteinosis: A case report and literature review.
%A Khan SNS
%A Stirling RG
%A Mclean CA
%A Russell PA
%A Hoy RF
%J Respirol Case Rep
%V 10
%N 9
%D Sep 2022
%M 35978719
暂无%R 10.1002/rcr2.1021
%X Pulmonary alveolar proteinosis (PAP) is a rare lung disease where there is accumulation of surfactant in the alveoli. It can be classified based on the underlying aetiology into three categories: primary, secondary and congenital. Autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF-Ab) are a key diagnostic feature of autoimmune PAP. High intensity occupational exposure and inhalation of toxic particles such as silica can cause a form of secondary PAP called acute silicoproteinosis. We describe a 26-year-old stone benchtop fabricator with silicoproteinosis following daily exposure to high levels of silica who had elevated serum GM-CSF-Ab. We discuss the role of GM-CSF-Ab in cases of PAP with occupational inhalational exposure and the challenges in its interpretation.