%0 Meta-Analysis
%T Single session versus multisession stereotactic radiosurgery for the management of intracranial meningiomas: a systematic review and meta-analysis.
%A Bin-Alamer O
%A Alnefaie N
%A Qedair J
%A Chaudhary A
%A Hallak H
%A Abdulbaki A
%A Mallela AN
%A Palmisciano P
%A Gersey ZC
%A Legarreta AD
%A Labib MA
%A Zada G
%A Sheehan JP
%A Couldwell WT
%A Lunsford LD
%A Abou-Al-Shaar H
%J J Neurooncol
%V 161
%N 2
%D Jan 2023
%M 35976546
%F 4.506
%R 10.1007/s11060-022-04112-6
%X <B>OBJECTIVE: </B>To compare the efficacy, outcomes, and complications of single session (SS-SRS) and multisession (MS-SRS) stereotactic radiosurgery in the treatment of intracranial meningiomas.<BR><B>METHODS: </B>Relevant articles were retrieved from PubMed, Scopus, Web of Science, and Cochrane. A systematic review and meta-analysis of treatment protocols and outcomes were conducted. After the selection process, 20 articles describing 1483 cases were included.<BR><B>RESULTS: </B>A total of 1303 patients who underwent SS-SRS and 180 patients who underwent MS-SRS for the management of their intracranial meningioma were reported in the included studies. SS-SRS and MS-SRS had comparable one-year (SS-SRS: 98% vs. MS-SRS: 100%, p > 0.99) and five-year (SS-SRS: 94% vs. MS-SRS: 93%, p = 0.71) tumor control rates. The groups also had comparable tumor volume reduction/tumor regression rates (SS-SRS: 44% vs. MS-SRS: 25%, p = 0.25), tumor volume stability rates (SS-SRS: 51% vs. MS-SRS: 75%, p = 0.12), and tumor progression rates (SS-SRS: 4% vs. MS-SRS: 4%, p = 0.89). SS-SRS and MS-SRS yielded similar complication rates (10.4% vs. 11.4%, p = 0.68) and comparable functional improvement rates (MS-SRS: 44% vs. SS-SRS: 36%, p = 0.57). However, MS-SRS was used for significantly larger tumor volumes (MS-SRS: 23.8 cm3 vs. SS-SRS: 6.1 cm3, p = 0.02).<BR><B>CONCLUSIONS: </B>SS-SRS and MS-SRS resulted in comparable tumor control, tumor volumetric change, and functional outcomes despite significant biases in selecting patients for SS- or MS-SRS.