%0 Journal Article
%T Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
%A Haddad RI
%A Bischoff L
%A Ball D
%A Bernet V
%A Blomain E
%A Busaidy NL
%A Campbell M
%A Dickson P
%A Duh QY
%A Ehya H
%A Goldner WS
%A Guo T
%A Haymart M
%A Holt S
%A Hunt JP
%A Iagaru A
%A Kandeel F
%A Lamonica DM
%A Mandel S
%A Markovina S
%A McIver B
%A Raeburn CD
%A Rezaee R
%A Ridge JA
%A Roth MY
%A Scheri RP
%A Shah JP
%A Sipos JA
%A Sippel R
%A Sturgeon C
%A Wang TN
%A Wirth LJ
%A Wong RJ
%A Yeh M
%A Cassara CJ
%A Darlow S
%J J Natl Compr Canc Netw
%V 20
%N 8
%D 08 2022
%M 35948029
%F 12.693
%R 10.6004/jnccn.2022.0040
%X Differentiated thyroid carcinomas is associated with an excellent prognosis. The treatment of choice for differentiated thyroid carcinoma is surgery, followed by radioactive iodine ablation (iodine-131) in select patients and thyroxine therapy in most patients. Surgery is also the main treatment for medullary thyroid carcinoma, and kinase inhibitors may be appropriate for select patients with recurrent or persistent disease that is not resectable. Anaplastic thyroid carcinoma is almost uniformly lethal, and iodine-131 imaging and radioactive iodine cannot be used. When systemic therapy is indicated, targeted therapy options are preferred. This article describes NCCN recommendations regarding management of medullary thyroid carcinoma and anaplastic thyroid carcinoma, and surgical management of differentiated thyroid carcinoma (papillary, follicular, Hürthle cell carcinoma).