%0 Case Reports
%T A Rare Case of Cleft Palate Associated With Tongue Hamartoma: A Case Report and Systematic Review.
%A Dash S
%A Chauhan S
%A Sennimalai K
%A Kharbanda OP
%A Singhal M
%J Cleft Palate Craniofac J
%V 60
%N 12
%D 12 2023 26
%M 35881509
%F 1.915
%R 10.1177/10556656221116001
%X Palate development involves a genetic regulation through a complex molecular mechanism that may be disrupted by environmental factors, resulting in impaired fusion and cleft palate formation. An encounter with a case of cleft palate due to dorsal tongue hamartoma prompted us to perform this systematic review.<BR>To review the clinical profile and management approach for a case with cleft palate and tongue hamartoma.<BR>A systematic literature search was conducted using keywords related to cleft palate and tongue hamartoma in PubMed, Scopus, MEDLINE, and Scielo databases through December 2021, with no time or language restrictions.<BR>Studies reporting patients with cleft palate and tongue hamartoma were included.<BR>Information related to clinical profile, diagnostic tests, histopathology, management, and outcomes were extracted.<BR>Fourteen relevant publications were identified with 16 cases reported so far. Among them, thirteen patients were females (81.25%), and 3 were males (18.75%). The age of presentation varied from birth to 19 years. Oral-facial-digital syndrome (type II) was the most commonly associated syndrome.<BR>Congenital tongue hamartoma with cleft palate is a rare presentation, which can present as an isolated entity or part of a syndrome. Genetic evaluation is warranted, particularly for multiple hamartomatous lesions. The preferred treatment is immediate excision of hamartoma while following a standard timeline for palatoplasty.