%0 Journal Article
%T Crack Sensing of Cardiomyocyte Contractility with High Sensitivity and Stability.
%A Wang L
%A Xu X
%A Chen J
%A Su W
%A Zhang F
%A Li A
%A Li C
%A Xu C
%A Sun Y
%J ACS Nano
%V 16
%N 8
%D 08 2022 23
%M 35867617
%F 18.027
%R 10.1021/acsnano.2c04260
%X Measuring myocardial contractility is of great value in exploring cardiac pathogenesis and quantifying drug efficacy. Among the biosensing platforms developed for detecting the weak contractility of a single layer of cardiomyocytes (CMs), thin brittle metal membrane sensors with microcracks are highly sensitive. However, their poor stability limits the application in long-term measurement. Here, we report a high stability crack sensor fabricated by deposition of a 105 nm thick Ag/Cr with microcracks onto a carbon nanotubes-polydimethylsiloxane (CNT-PDMS) layer. This brittle-tough bilayer crack sensor achieved high sensitivity (gauge factor: 108 241.7), a wide working range (0.01-44%), and high stability (stable period >2 000 000 cycles under the strain caused by a monolayer of CMs). During 14-day continuously monitoring CMs culturing and drug treatment testings, the device demonstrated high sensitivity and stability to record the dynamic change caused by contractility of the CMs.