%0 Journal Article
%T Lymphocyte alterations in patients with Common Variable Immunodeficiency (CVID) and autoimmune manifestations.
%A Rossi S
%A Baronio M
%A Gazzurelli L
%A Tessarin G
%A Baresi G
%A Chiarini M
%A Moratto D
%A Badolato R
%A Plebani A
%A Lougaris V
%J Clin Immunol
%V 241
%N 0
%D 08 2022
%M 35843508
%F 10.19
%R 10.1016/j.clim.2022.109077
%X Autoimmunity is a common feature in CVID patients. To date the mechanisms leading to the development of such complications are not fully elucidated.<BR>Data from 122 CVID patients subdivided in three groups based on the absence of autoimmunity (n-AI) or the presence of hematologic autoimmune phenomena (Cy-AI) or non-hematologic autoimmune phenomena (n-Cy-AI) were evaluated.<BR>We identified a total of 128 autoimmune manifestations in 55/122 patients (45.1%). 30/122 (24.6%) patients presented hematologic autoimmune phenomena while 29/122 (23.8%) presented gastrointestinal autoimmune involvement. Immune thrombocytopenia was the most common manifestation (27/122; 22.1%), followed by autoimmune hemolytic anemia (18/122; 14.8%) and autoimmune enteropathy (17/122; 13.9%). Cy-AI patients displayed higher CD4+ effector memory and terminally differentiated CD8+ cells with lower percentages of naïve and recent thymic emigrants (RTEs) CD4+ cells and a significant expansion of the CD19hiCD21low population.<BR>CVID patients developing autoimmune cytopenias display characteristic immune phenotypic features.